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Unlike methyl-B12, it does not directly donate methyl groups and can actually help buffer excess methylation

A key metabolic junction in targeted tumor therapy

In VDR-deficient mice, LCs display a hypermature phenotype characterized by enhanced antigen presentation and proinflammatory features, providing additional evidence that 1,25(OH)D serves as an immune brake in the cutaneous mucosal environment [147, 148]

They not only affect the stability of the drug in vivo but also determine the manner and timing of active payload release

While IV therapy is highly effective because it delivers the antioxidant directly into the bloodstream, bypassing the digestive tract entirely, it is also expensive, invasive, and impractical for daily, long-term management